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Trusopt and Pregnancy

Problems that occurred when high doses of Trusopt (dorzolamide) were given to pregnant rabbits include low fetal weight and malformation in the fetal vertebrae. Based on the results of these studies, the eye drops have been given a pregnancy Category C rating. This means Trusopt may be prescribed as long as the benefits to the woman outweigh the risks to the fetus.

I'm Pregnant -- Can I Use Trusopt?

Trusopt® (dorzolamide hydrochloride) is a medication approved for the treatment of high eye pressure and open-angle glaucoma. At this time, it is unclear if Trusopt is safe for use during pregnancy.
It is important to understand that even though Trusopt is an eye drop, some of the medication reaches the bloodstream and could therefore affect a developing fetus.

What Is Pregnancy Category C?

The U.S. Food and Drug Administration (FDA) uses a category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Pregnancy Category C is given to medicines that have not been studied in pregnant humans, but do appear to cause harm to the fetus in animal studies.
In addition, medicines that have not been studied in any pregnant women or animals are automatically given a pregnancy Category C rating.
Trusopt was given a pregnancy Category C rating because of problems seen in animal studies. Giving pregnant rabbits exceptionally high doses of Trusopt by mouth, instead of as an eye drop caused malformation in the fetal vertebrae. These doses were also high enough to cause metabolic acidosis (overly acidic bodily fluids) and poor weight gain in the mother rabbits and low fetal weight. Lower doses (which were still several times higher than recommended) did not cause such problems.
It is important to note that animals do not always respond to medicines in the same way that humans do. Therefore, a pregnancy Category C medicine may be given to a pregnant woman if the healthcare provider believes that the benefits to the woman outweigh any possible risks to the unborn child.
Pregnancy and Pain

Trusopt Eye Drop Information

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