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Rescula Warnings and Precautions

If you are going to use Rescula, it is important to know that this medication can sometimes cause problems, such as darkening of the iris, macular edema, or other eye problems. Other safety precautions with Rescula involve warnings about receiving this drug while pregnant or breastfeeding. Also, you may not be able to use this medication if you have certain allergies.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to using Rescula® (unoprostone ophthalmic solution) if you have:
  • An eye infection or eye swelling
  • An inflammatory eye condition, such as iritis or uveitis
  • Had eye surgery
  • Any condition that increases your risk for macular edema (swelling of the macula, an area of the retina), such as diabetes
  • Any allergies, including to medications, foods, dyes, or preservatives.
Also, let your healthcare provider know if you:
  • Wear contact lenses
  • Are pregnant or thinking of becoming pregnant
  • Are breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings for Rescula

Some warnings and precautions to be aware of prior to using this medication include the following:
  • Rescula can cause a gradual darkening of the iris (the colored part of the eye). Typically, the iris, or part of the iris, becomes a deep brown color. This change in eye color may not be noticeable for months or even years. This potential side effect is not dangerous, and you can continue to use the medicine even if it occurs. However, the change in eye color is usually permanent.
  • Rescula can also darken the eyelid and eyelashes. Unlike changes in eye color, eyelid and eyelash color usually return to normal once the medicine is stopped.
  • This medicine can worsen eye inflammation. Let your healthcare provider know if you have an inflammatory condition of the eye, such as uveitis. Your healthcare provider may need to monitor you more closely if you have a flare-up of your condition or active inflammation.
  • There have been cases of macular edema occurring in people treated with Rescula. Macular edema is an eye condition in which swelling occurs in the macula (the small area of the retina responsible for detailed central vision). Macular edema can lead to loss of vision. Let your healthcare provider know if you have any changes in vision, which could be a sign of macular edema.  
  • There have been reports of bacterial keratitis (a potentially serious infection of the cornea) occurring in people using multiple-dose eye products, such as Rescula. In order to keep the bottle germ-free, and help minimize the risk for infection, do not allow the tip of the dropper to touch any surface. This includes your eye, eyelid, and fingers.
  • Rescula contains benzalkonium chloride, a preservative that can be absorbed by soft contact lenses. If you wear contacts, remove them before using Rescula, and wait at least 15 minutes after your dose to reinsert them.
  • Rescula is a pregnancy Category C medication, which means it may not be safe for use during pregnancy, although the full risks are currently unknown (see Rescula and Pregnancy for more information).
  • It is unknown if Rescula passes through breast milk. Therefore, if you are breastfeeding a child, check with your healthcare provider before using this product (see Rescula and Breastfeeding).

Rescula Medication Information

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