Glaucoma Home > Zioptan Warnings and Precautions

To help ensure your safety with Zioptan, your healthcare provider needs to know if you have a history of certain inflammatory eye conditions or any allergies. Also, make sure you know exactly how to use the eye drops, particularly if you are using them in combination with other eye products. Other precautions and warnings for Zioptan apply to women who are pregnant or breastfeeding.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to using Zioptan® (tafluprost ophthalmic solution) if you:
  • Have an inflammatory eye condition, such as iritis or uveitis
  • Have any allergies, including to foods, dyes, or preservatives
  • Are pregnant or thinking of becoming pregnant
  • Are breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings With Zioptan

Some warnings and precautions to be aware of prior to using these eye drops include the following:
  • Zioptan can cause increased pigmentation (darkening) of certain tissues. It can cause a darkening of the iris (the colored part) of the eyes, the eyelids, and the eyelashes.

While darkening of the eyelids and eyelashes usually improves after Zioptan is stopped, eye darkening is usually permanent. This eye darkening is most noticeable in people with light-colored eyes (such as blue eyes), as Zioptan tends to make the eyes more brown. These changes are not dangerous, and you can keep using Zioptan if they occur.

  • Zioptan can also cause longer and thicker eyelashes, as well as eyelashes that grow in the wrong directions.
  • There have been reports of macular edema (swelling of the macula of the eye) in some people who used Zioptan. Make sure to let your healthcare provider know if you have any vision changes, as they may be a sign of macular edema.
  • People with a history of iritis or uveitis (certain inflammatory conditions of the eye) should generally not use Zioptan. These eye drops should typically be avoided if you currently have eye inflammation.
  • Zioptan is not approved for angle closure glaucoma, inflammatory glaucoma, or neovascular glaucoma, as it has not been thoroughly studied for these types of glaucoma.
  • If you develop any eye condition or require eye surgery, let your healthcare provider know. You may be advised to temporarily stop using Zioptan.
  • Wait at least five minutes in between using Zioptan and any other eye drops.
  • Zioptan is a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are currently unknown (see Zioptan and Pregnancy).
  • It is unknown if Zioptan passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to using the drops (see Zioptan and Breastfeeding).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
List of references (click here):
Other Articles in This eMedTV Presentation

Topics & Medications


Related Channels

eMedTV Links
Copyright © 2006-2020 Clinaero, Inc.

eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click Terms of Use for more information.

This site complies with the HONcode standard for trustworthy health information:
verify here.