Glaucoma Home > Mitosol Warnings and Precautions

If you are going to receive Mitosol during eye surgery, it is important to know that this medication can cause problems, such as cornea damage, low eye pressure, or other eye problems. Other safety precautions with Mitosol involve warnings about receiving this drug while pregnant or breastfeeding. Also, you may not be able to receive this medication if you have certain allergies.


What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to receiving Mitosol® (mitomycin ophthalmic) if you have:
  • Had eye surgery in the past
  • Any allergies, including to medications, foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings for Mitosol

Some warnings and precautions to be aware of prior to receiving this medication include the following:
  • Mitosol can cause cell death. If used in high doses or left on the eye too long, it may damage the cornea (the clear outermost layer of the eye) or sclera (the white outer wall of the eye). This drug should only be applied topically at the recommended dose and left on the eye for no longer than two minutes. It should not be injected into the eye.
  • People treated with this medicine may be more likely to develop low eye pressure (intraocular pressure) after surgery. Low intraocular pressure, known medically as hypotony, can decrease vision.
  • Mitosol may increase the risk for changes in the lens of the eye and cataracts (clouding of the lens), especially in people who have never had cataract surgery or other surgery to remove their natural lens. 
  • Mitosol is a pregnancy Category X medication, which means that it may be harmful if used during pregnancy (see Mitosol and Pregnancy for more information).
  • It is unknown if this drug passes through breast milk. Therefore, if you are breastfeeding or plan to start, check with your healthcare provider before receiving it (see Mitosol and Breastfeeding).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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