Glaucoma Home > Combigan Uses

How Does Combigan Work?

As previously stated, Combigan contains two different active ingredients, brimonidine tartrate and timolol maleate.
Brimonidine belongs to a group of drugs called alpha adrenergic agonists (often known as just "alpha agonists"). Brimonidine binds to and activates alpha receptors in the eye, causing two important effects. It decreases the amount of fluid (known as aqueous humor) the eye produces and increases the rate of drainage. These two effects result in lowered eye pressure.
Timolol belongs to a group of drugs called beta-adrenergic blocking agents, more commonly known as beta blockers. As the name implies, these medications block beta receptors in the body. Beta receptors are located in a number of places within the body, including the eye. Beta blockers also lower the pressure in the eye by decreasing the amount of fluid the eye produces.

Can Children Use It?

Combigan has been shown to be safe and effective for use in children as young as two years of age. However, it's a good idea to ask your child's healthcare provider about the benefits and risks of any medication he or she recommends for your child, including Combigan. This drug is not recommended for children under two years of age, as there have been reports of serious side effects in this age group.

Off-Label Uses for Combigan

On occasion, your healthcare provider may recommend this product for something other than high eye pressure or open-angle glaucoma (this would be known as an "off-label" use). At this time, using Combigan to treat acute angle-closure glaucoma would be an off-label use.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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