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Istalol Drug Interactions

Istalol Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Istalol is combined with any of the drugs listed above.
 
Calcium Channel Blockers
Combining Istalol with certain calcium channel blockers may cause dangerously low blood pressure or a dangerously slow heart rate (bradycardia). You may need to be monitored very closely if you take these medications together. In some cases, it is not recommended to combine Istalol with a calcium channel blocker.
 
Clonidine
Stopping clonidine (without stopping the Istalol) could increase the risk of dangerously high blood pressure, strokes, and other serious problems. This is more common with oral beta blockers, but could potentially happen with Istalol as well. If you need to stop taking clonidine, ask your healthcare provider for further instructions.
 
CYP 2D6 Inhibitors
Istalol is metabolized by a specific liver enzyme known as CYP 2D6. Some other medications (known as CYP 2D6 inhibitors) slow down the activity of this enzyme, causing an increase in the level of Istalol in the blood and potentially serious Istalol side effects. Different medications inhibit the enzyme to different extents; some interactions may be minor, while others may be quite severe. Check with your healthcare provider before combining Istalol with a CYP 2D6 inhibitor.
 
Digoxin
Combining Istalol with digoxin may cause a dangerously slow heart rate (bradycardia). You may need to be monitored very closely if you take these medications together. In some cases, it is not recommended to combine Istalol with digoxin.
 
Epinephrine
Istalol may decrease the effectiveness of injectable epinephrine for treating allergic reactions. If you have a serious allergy that may potentially require treatment with epinephrine, Istalol might not be a good choice for you.
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