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Combigan Warnings and Precautions

Before using Combigan eye drops, tell your healthcare provider if you have Raynaud's disease, asthma, diabetes, or any allergies. It's important to note that this product can mask symptoms of low blood sugar, which can cause serious problems for people with diabetes. Other warnings and precautions for Combigan apply to people with heart failure or who are about to have eye surgery.

What Should I Tell My Healthcare Provider?

Prior to using Combigan® (brimonidine/timolol), tell your healthcare provider if you have:
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings With Combigan

Warnings and precautions to be aware of prior to using these eye drops include the following:
  • Combigan should be used with caution in people with the following conditions:
    • Depression
    • Heart disease
    • Raynaud's disease
    • A history of a stroke
    • Low blood pressure
    • Thromboangiitis obliterans.
There is a small chance that Combigan could make such conditions worse. However, many people with such conditions can safely use Combigan with no problems whatsoever.
  • This medicine may worsen allergic reactions and may make epinephrine (one of the standard treatments for life-threatening allergic reactions) less effective. If you have a history of severe allergic reactions, Combigan (or any other beta blocker) may not be the best choice for you.
  • Like all beta blockers, Combigan can worsen heart failure in some situations. If you have heart failure, your healthcare provider may need to monitor you very closely while you use Combigan. Let your healthcare provider know immediately if your heart failure symptoms seem to worsen.
  • Beta blockers can worsen breathing problems like asthma or COPD. In many cases, Combigan is not recommended for people with such lung problems.
  • This product may worsen myasthenia gravis symptoms or may even cause it. Let your healthcare provider know if you develop symptoms of this problem, such as muscle weakness, double vision, or a droopy eyelid.
  • If you will be having surgery, make sure your surgeon and anesthesiologist know you use Combigan, as it may affect the choice of medications used during the surgery.
  • Beta blockers can mask some of the symptoms of low blood sugar (hypoglycemia), particularly the "racing heart" feeling. This can cause serious problems for people with diabetes, who need to be able to sense that they have low blood sugar in order to correct it before it becomes life-threatening. Some beta blockers may also worsen low blood sugar, although it is not known if this is a problem with Combigan.
  • Beta blockers can mask some of the symptoms of an overactive thyroid (hyperthyroidism).
  • Combigan can potentially interact with a number of other medications (see Combigan Drug Interactions).
  • If you wear soft contact lenses, be sure to remove them before each dose of Combigan and wait at least 15 minutes before reinserting them. This medication contains a preservative (benzalkonium chloride) that can bind to soft contact lenses.
  • This product can potentially interact with some other medications (see Combigan Drug Interactions).
  • If you will be having eye surgery or develop any other eye problems or conditions (such as an infection), check with your healthcare provider about whether you should continue to use these eye drops.
  • If you use other eye drops, be sure to separate your Combigan dosage from that of the other drops by at least 10 minutes.
  • Combigan is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are not currently known (see Combigan and Pregnancy).
  • At least one of the active ingredients in Combigan passes through breast milk in humans. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to using the eye drops (see Combigan and Breastfeeding).

Combigan Eye Drops

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