Combigan Drug Interactions
It is dangerous to combine methacholine with Combigan. Doing so could cause severe, asthma-like breathing problems that are not easily corrected. These medications should never be combined.
Monoamine Oxidase Inhibitors (MAOIs)
Combigan should never be combined with an MAOI, due to the risk of serious reactions.
Other Beta Blockers
Combigan contains a beta blocker. Caution should be used if it is used with other beta blockers, especially oral beta blockers. Such combinations may increase the risk of side effects. In addition, it is not recommended to use two different beta blocker eye drops at the same time.
Combining reserpine with a beta blocker can increase the risk of serious side effects. You may need to be monitored very closely if you use these medications together. In some cases, Combigan and reserpine should not be combined.
Other Eye Medications
If you use other eye medications, be sure to separate your Combigan dosage from that of the other medications by at least 10 minutes.
Theoretically, tricyclic antidepressants may decrease the effectiveness of Combigan, although it is unclear how significant this potential interaction actually is.