Combigan Drug Interactions
Combigan Drug Interactions ExplainedThe following sections explain in detail the potentially negative interactions that can occur when Combigan is combined with any of the drugs listed above.
Calcium Channel Blockers
Combining Combigan with calcium channel blockers may cause dangerously low blood pressure and, with certain calcium channel blockers, may cause a dangerously slow heart rate (bradycardia). You may need to be monitored very closely if you use these medications together. In some cases, Combigan should not be combined with a calcium channel blocker.
Stopping clonidine without stopping Combigan could increase the risk of dangerously high blood pressure, strokes, and other serious problems. This is more common with oral beta blockers, but could happen with Combigan as well. If you need to stop taking clonidine, ask your healthcare provider for further instructions.
CYP 2D6 Inhibitors
Combigan is metabolized by a specific liver enzyme known as CYP 2D6. Some other medications, known as CYP 2D6 inhibitors, slow down the activity of this enzyme, causing an increase in the level of Combigan in the blood. This could lead to serious Combigan side effects.
Different medications inhibit the enzyme to different extents; some interactions may be minor, while others may be quite severe. Check with your healthcare provider before combining Combigan with a CYP 2D6 inhibitor.
Using Combigan with digoxin may cause a dangerously slow heart rate (bradycardia). You may need to be monitored very closely if you use these medications together. In some cases, Combigan and digoxin should not be combined.
Combigan may decrease the effectiveness of injectable epinephrine for treating allergic reactions. If you have a serious allergy that may require treatment with epinephrine, Combigan might not be a good choice for you.